Phytic acid exerts protective effects in cerebral ischemia-reperfusion injury by activating the anti-oxidative protein sestrin2-Reference-Cited by-同舟云学术

Phytic acid exerts protective effects in cerebral ischemia-reperfusion injury by activating the anti-oxidative protein sestrin2

Published:2020-07-02 Issue:7 Volume:84 Page:1401-1408
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Liu Jing¹,Li Ying²,Mei Chunli³,Ning Xianbin⁴,Pang Jinfeng⁴,Gu Lei²,Wu Liang²

Affiliation:

1. Neurology Department, Affiliated Hospital of Beihua University, Jilin, China

2. Rehabilitation Center, Beijing Xiaotangshan Hospital, Beijing, China

3. Neurology Department, Beihua University, Jilin, China

4. Neurosurgery Department, Affiliated Hospital of Beihua University, Jilin, China

Abstract

Abstract Cerebral ischemia reperfusion (I/R) is a therapeutic strategy for ischemia; however, it usually causes injury by the aspect of inflammation and neuron apoptosis. This investigation aims to investigate the protective effects of phytic acid (IP6) for cerebral I/R injury in vitro. PC-12 cells under Oxygen and glucose deprivation/reperfusion (OGD/R) were performed to mimic cerebral I/R. IP6 was pretreated before PC-12 cells under OGD/R treatment. The data showed that IP6 activated the expression of sestrin2 in OGD/R injured PC-12 cells. IP6 inhibited OGD/R induced inflammation, oxidative stress, and apoptosis by activating sestrin2. Besides, p38 MAPK may mediate the effects of sestrin2 activated by IP6. Therefore, IP6 can be a potential drug to prevent neurological damage in cerebral I/R injury.

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/84/7/1401/36827492/bbb1401.pdf

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