A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response

Author:

Rubio-Pérez Laura1234ORCID,Lázaro-Gorines Rodrigo123ORCID,Harwood Seandean L.5ORCID,Compte Marta6ORCID,Navarro Rocío6ORCID,Tapia-Galisteo Antonio123ORCID,Bonet Jaume7ORCID,Blanco Belén123ORCID,Lykkemark Simon8ORCID,Ramírez-Fernández Ángel123ORCID,Ferreras-Gutiérrez Mariola9ORCID,Domínguez-Alonso Carmen123ORCID,Díez-Alonso Laura123ORCID,Segura-Tudela Alejandro123ORCID,Hangiu Oana126,Erce-Llamazares Ainhoa126,Blanco Francisco J.9ORCID,Santos Cruz10ORCID,Rodríguez-Peralto José L.11121314ORCID,Sanz Laura1415ORCID,Álvarez-Vallina Luis1234ORCID

Affiliation:

1. Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Spain

2. Immuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, Spain

3. H12O-CNIO Cancer Immunotherapy Clinical Research Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

4. Chair for Immunology UFV/Merck, Universidad Francisco de Vitoria (UFV), Madrid, Spain

5. Department of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark

6. Department of Antibody Engineering, Leadartis SL, QUBE Technology Park, Madrid, Spain

7. Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

8. Immunotherapy and Cell Engineering Laboratory, Department of Engineering, Aarhus University, Aarhus C, Denmark

9. Centro de Investigaciones Biológicas Margarita Salas (CIB), CSIC, Madrid, Spain

10. Faculty of Experimental Sciences, Universidad Francisco de Vitoria (UFV), Madrid, Spain

11. Department of Pathology, Hospital Universitario 12 de Octubre, Madrid, Spain

12. Department of Pathology, Universidad Complutense, Madrid, Spain

13. Cutaneous Oncology Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, Spain

14. Centro de Investigación Biomédica en Red en Oncología (CIBERONC), Madrid, Spain

15. Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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