The diverse functions of the PD1 inhibitory pathway
Author:
Publisher
Springer Science and Business Media LLC
Subject
Energy Engineering and Power Technology,Fuel Technology
Link
http://www.nature.com/articles/nri.2017.108.pdf
Reference172 articles.
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2. Dong, H., Zhu, G., Tamada, K. & Chen, L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 5, 1365–1369 (1999).
3. Freeman, G. J. et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192, 1027–1034 (2000). References 2 and 3 provide the first descriptions of PDL1; reference 3 also identified PDL1 as a binding partner for PD1.
4. Latchman, Y. et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. 2, 261–268 (2001).
5. Tseng, S. Y. et al. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 193, 839–846 (2001). References 4 and 5 present the first descriptions of PDL2 as a second ligand for PD1. Reference 4 also provides one of the first descriptions of PDL1 and PDL2 expression by tumour cells.
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