Pharmacokinetics and safety of LEAD-452, an EGFR-specific 4-1BB-agonistic trimerbody in non-human primates

Author:

Navarro Rocío,Frago Susana,Hangiu Oana,Erce-Llamazares Ainhoa,Lázaro-Gorines Rodrigo,Morcillo Miguel A.,Rodriguez-Peralto José L.,Sanz Laura,Compte Marta,Alvarez-Vallina Luis

Publisher

Elsevier BV

Reference40 articles.

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2. Organ weights in relation to age and sex in cynomolgus monkeys (Macaca fascicularis);Amato;Toxicol. Pathol.,2022

3. Reference intervals and percentiles for hematologic and serum biochemical values in captive bred rhesus (Macaca mulatta) and cynomolgus macaques (Macaca fascicularis);Bakker;Animals (Basel),2023

4. Safety evaluation to support first-in-man investigations II: toxicology studies;Baldrick;Regul. Toxicol. Pharmacol.,2008

5. Activation of 4-1BB on liver myeloid cells triggers hepatitis via an interleukin-27–dependent pathway;Bartkowiak;Clin. Cancer Res.,2018

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