Direct and quantitative evaluation of the major human CYP contribution (fmCYP) to drug clearance using the in vitro Silensomes™ model-Reference-Cited by-同舟云学术

Direct and quantitative evaluation of the major human CYP contribution (fmCYP) to drug clearance using the in vitro Silensomes™ model

Published:2018-01-10 Issue:1 Volume:49 Page:22-35
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Parmentier Yannick¹,Pothier Corinne¹,Hewitt Nicola²,Vincent Ludwig¹,Caradec Fabrice¹,Liu Jia³,Lin Feifei³,Trancart Marie-Michèle⁴,Guillet Fabrice⁴,Bouaita Belkacem⁵,Chesne Christophe⁵,Walther Bernard¹

Affiliation:

1. Department of Biopharmaceutical Research, Technologie Servier, Orléans Cedex, France,

2. Scientific Writing Services, Erzhausen, Germany,

3. SIMM-SERVIER Joint Biopharmacy Laboratory, Shanghai Institute of Materia Medica, Shanghai, China,

4. Eurosafe, Saint-Grégoire, France, and

5. Biopredic International, Rennes, France

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2017.1422156

Reference62 articles.

1. The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan

2. Impact of theCYP2C8*3polymorphism on the drug-drug interaction between gemfibrozil and pioglitazone

3. Effects of Clopidogrel on the Pharmacokinetics of Sibutramine and Its Active Metabolites

4. Benzylic Oxidation of Gemfibrozil-1-O-β-Glucuronide by P450 2C8 Leads to Heme Alkylation and Irreversible Inhibition

5. Geneva Cocktail for Cytochrome P450 and P-Glycoprotein Activity Assessment Using Dried Blood Spots

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