Benzylic Oxidation of Gemfibrozil-1-O-β-Glucuronide by P450 2C8 Leads to Heme Alkylation and Irreversible Inhibition
Author:
Affiliation:
1. Department of Drug Metabolism, Array Biopharma Inc., 3200 Walnut Street, Boulder, Colorado 80301
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/tx900105n
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1. Gemfibrozil greatly increases plasma concentrations of cerivastatin
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3. Gemfibrozil considerably increases the plasma concentrations of rosiglitazone
4. Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone
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