Predicting successful/unsuccessful extrapolation for in vivo total clearance of model compounds with a variety of hepatic intrinsic metabolism and protein bindings in humans from pharmacokinetic data using chimeric mice with humanised liver-Reference-Cited by-同舟云学术

Predicting successful/unsuccessful extrapolation for in vivo total clearance of model compounds with a variety of hepatic intrinsic metabolism and protein bindings in humans from pharmacokinetic data using chimeric mice with humanised liver

Published:2019-09-13 Issue:5 Volume:50 Page:526-535
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Sawada Takeshi¹,Yamaura Yoshiyuki¹,Higuchi Satonori²,Imawaka Haruo¹,Yamazaki Hiroshi³^ORCID

Affiliation:

1. Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd, Tsukuba, Japan;

2. Corporate Planning Department, Ono Pharmaceutical Co., Ltd, Osaka, Japan;

3. Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2019.1664791

Reference19 articles.

1. Pharmacokinetics of benzydamine after intravenous, oral, and topical doses to human subjects

2. Prediction of Human Pharmacokinetics From Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches

3. EXPRESSION OF HUMAN CYTOCHROMES P450 IN CHIMERIC MICE WITH HUMANIZED LIVER

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