Empirical and theoretical approaches for the prediction of human hepatic clearance using chimeric mice with humanised liver: the use of physiologically based scaling, a novel solution for potential overprediction due to coexisting mouse metabolism-Reference-Cited by-同舟云学术

Empirical and theoretical approaches for the prediction of human hepatic clearance using chimeric mice with humanised liver: the use of physiologically based scaling, a novel solution for potential overprediction due to coexisting mouse metabolism

Published:2021-07-15 Issue:9 Volume:51 Page:983-994
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Matsumoto Shogo¹,Kamimura Hidetaka²,Nishiwaki Megumi³,Cho Naoki¹,Kato Kazuhiko¹,Yamamoto Taichi⁴

Affiliation:

1. Meiji Seika Pharma Co., Ltd., Pharmaceutical Research Labs, Yokohama, Japan

2. Laboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki, Japan

3. CLEA Japan Inc, Meguro-ku, Japan

4. In Vivo Science Inc, Kawasaki, Japan

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2021.1950865

Reference42 articles.

1. Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice

2. A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism

3. On the prediction of hepatic clearance using the diluted plasma in metabolic stability assay

4. Prediction of Hepatic Clearance in Human From In Vitro Data for Successful Drug Development

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1. Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css–MRTpo method and chimeric mice with humanised livers;Xenobiotica;2023-09-02

2. Formation of reactive metabolites of benzbromarone in humanized-liver mice;Drug Metabolism and Pharmacokinetics;2022-12