Comparison of the hepatic metabolism of triazolam in wild-type andCyp3a-knockout mice for understanding CYP3A-mediated metabolism inCYP3A-humanised mice in vivo-Reference-Cited by-同舟云学术

Comparison of the hepatic metabolism of triazolam in wild-type andCyp3a-knockout mice for understanding CYP3A-mediated metabolism inCYP3A-humanised mice in vivo

Published:2019-06-14 Issue:11 Volume:49 Page:1303-1310
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Minegishi Genki¹,Kazuki Yasuhiro²³,Yamasaki Yuki¹,Okuya Fuka¹,Akita Hidetaka¹,Oshimura Mitsuo²,Kobayashi Kaoru¹

Affiliation:

1. Laboratory of DDS design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan;

2. Chromosome Engineering Research Center, Tottori University, Tottori, Japan;

3. Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Tottori, Japan

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2018.1560516

Reference41 articles.

1. Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology

2. Species Differences in Mechanism-Based Inactivation of CYP3A in Humans, Rats and Mice

3. Comparison of xenobiotic-metabolising human, porcine, rodent, and piscine cytochrome P450

4. RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome

5. P-Glycoprotein Increases Portal Bioavailability of Loperamide in Mouse by Reducing First-Pass Intestinal Metabolism

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