Application of unbound liver-to-plasma concentration ratio to quantitative projection of cytochrome P450-mediated drug–drug interactions using physiologically based pharmacokinetic modelling approach-Reference-Cited by-同舟云学术

Application of unbound liver-to-plasma concentration ratio to quantitative projection of cytochrome P450-mediated drug–drug interactions using physiologically based pharmacokinetic modelling approach

Published:2019-02-03 Issue:11 Volume:49 Page:1251-1259
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Iwasaki Shinji¹²,Kosugi Yohei¹,Zhu Andy Z.X.²,Nakagawa Sayaka¹,Sano Noriyasu¹,Funami Miyuki¹,Kosaka Mai¹,Furuta Atsutoshi¹,Hirabayashi Hideki¹,Amano Nobuyuki¹

Affiliation:

1. Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd., Fujisawa, Kanagawa, Japan;

2. Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., Cambridge, MA, USA

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2018.1547461

Reference45 articles.

1. Lack of effect of omeprazole treatment on steady-state plasma levels of metoprolol

2. Comparative effects of the diastereoisomers, quinine and quinidine in producing phenocopy debrisoquine poor metabolisers (PMs) in healthy volunteers