Determination of Fraction Unbound and Unbound Partition Coefficient to Estimate Intracellular Free Drug Concentration
Author:
Publisher
Springer US
Link
https://link.springer.com/content/pdf/10.1007/978-1-0716-1250-7_4
Reference29 articles.
1. Smith DA, Di L, Kerns EH (2010) The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery. Nat Rev Drug Discov 9:929–939
2. Riccardi K, Li Z, Brown JA, Gorgoglione MF, Niosi M, Gosset J, Huard K, Erion DM, Di L (2016) Determination of unbound partition coefficient and in vitro-in vivo extrapolation for SLC13A transporter-mediated uptake. Drug Metab Dispos 44:1633–1642
3. Riccardi K, Lin J, Li Z, Niosi M, Ryu S, Hua W, Atkinson K, Kosa RE, Litchfield J, Di L (2017) Novel method to predict in vivo liver-to-plasma Kpuu for OATP substrates using suspension hepatocytes. Drug Metab Dispos 45:576–580
4. Zhang D, Hop CE, Kenny JR, Nagapudi K, Zak M, Wright MR, Zang R, Khojasteh SC, Patilea-Vrana G, Unadkat JD, Gampa G, Seneviratne HK, Bumpus NN, Di L, Zhou L, Liu X, Lai Y (2019) Drug concentration asymmetry in tissues and plasma for small molecule-related therapeutic modalities. Drug Metab Dispos 47:1122–1135
5. Riccardi KA, Tess DA, Lin J, Patel R, Ryu S, Atkinson K, Di L, Li R (2019) A novel unified approach to predict human hepatic clearance for both enzyme- and transporter-mediated mechanisms using suspended human hepatocytes. Drug Metab Dispos 47:484–492
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