An Efficient Synthesis Of Acyclic N7- and N9-Adenine Nucleosides Via Alkylation With Secondary Carbon Electrophiles to Introduce Versatile Functional Groups At the C-1 Position of Acyclic Moiety-Reference-Cited by-同舟云学术

An Efficient Synthesis Of Acyclic N7- and N9-Adenine Nucleosides Via Alkylation With Secondary Carbon Electrophiles to Introduce Versatile Functional Groups At the C-1 Position of Acyclic Moiety

Published:2006-01 Issue:2 Volume:25 Page:121-140
ISSN:1525-7770
Container-title:Nucleosides, Nucleotides and Nucleic Acids
language:en
Short-container-title:Nucleosides, Nucleotides and Nucleic Acids

Author:

Kotian Pravin L.,Kumar V. Satish,Lin Tsu-Hsing,El-Kattan Yahya,Ghosh Ajit,Wu Minwan,Cheng Xiaogang,Bantia Shanta,Babu Yarlagadda S.,Chand Pooran

Publisher

Informa UK Limited

Subject

Genetics,Molecular Medicine,Biochemistry,General Medicine

Link

http://www.tandfonline.com/doi/pdf/10.1080/15257770500446816

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1. 9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group

2. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine

3. The activity in vitro against herpes virus of 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine), a new antiviral agent

4. A new nucleoside analog, 9-[[2-hydroxy-1-(hydroxymethyl)ethoxyl]methyl]guanine, highly active in vitro against herpes simplex virus types 1 and 2

5. Activation by thymidine kinase and potent antiherpetic activity of 2′-nor-2′-deoxyguanosine (2′NDG)

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