The development of original methodologies of directed synthesis of le-Carbs their analogs and precursors base donacetylene and its derivatives-Reference-Cited by-同舟云学术

The development of original methodologies of directed synthesis of le-Carbs their analogs and precursors base donacetylene and its derivatives

Published:2017-03-29 Issue: Volume: Page:
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Container-title:Topical issues of translational medicine
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Author:

Трофимов Б.¹,Trofimov B.²,Гусарова Н.¹,Gusarova N.²

Affiliation:

1. Иркутский институт химии им. А.Е. Фаворского СО РАН

2. Irkutskiy institut himii im. A.E. Favorskogo SO RAN

Abstract

New reactions, which have been discovered and continue to be developed in A.E. Favorsky Irkutsk institute of chemistry SB RAS on the basis of acetylene, a product of oil, gas and coal processing and multi-faceted building block for organic synthesis, have been considered. These reactions provide for the shortest routes to construction of fundamental heterocyclic scaffolds (pyrroles, imidazoles, pyrazoles, indoles, pyridines, dihydropyridines, etc.) with desirable and optimum combination of functional pharmacophoric groups and fragments, which are responsible for antiviral (HIV, flu), antitumor, tuberculostatic and hypotensive activities.

Publisher

INFRA-M Academic Publishing LLC.

Reference67 articles.

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