Drug discovery strategies for novel leukotriene A4 hydrolase inhibitors-Reference-Cited by-同舟云学术

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Drug discovery strategies for novel leukotriene A4 hydrolase inhibitors

Published:2021-07-16 Issue:12 Volume:16 Page:1483-1495
ISSN:1746-0441
Container-title:Expert Opinion on Drug Discovery
language:en
Short-container-title:Expert Opinion on Drug Discovery

Author:

Röhn Till A¹^ORCID,Numao Shin²^ORCID,Otto Heike¹^ORCID,Loesche Christian³^ORCID,Thoma Gebhard⁴^ORCID

Affiliation:

1. Autoimmunity, Transplantation and Inflammation, Novartis Institutes for Biomedical Research, Basel, Switzerland

2. Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Basel, Switzerland

3. Translational Medicine, Novartis Institutes for Biomedical Research, Basel, Switzerland

4. Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Basel, Switzerland

Funder

authors are funded by Novartis Pharma AG

Publisher

Informa UK Limited

Subject

Drug Discovery

Link

https://www.tandfonline.com/doi/pdf/10.1080/17460441.2021.1948998

Reference89 articles.

1. The Leukotrienes: Immune-Modulating Lipid Mediators of Disease

2. Leukotrienes

3. Cytosolic phospholipase A2: physiological function and role in disease

4. 5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease

5. Leukotrien A4 hydrolase and the committed step in leukotriene B4 biosynthesis

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1. The analgesic effects of Yu-Xue-Bi tablet (YXB) on mice with inflammatory pain by regulating LXA4-FPR2-TRPA1 pathway;Chinese Medicine;2024-08-06

2. Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor;Journal of Medicinal Chemistry;2024-03-13

3. LTA4H inhibitor LYS006: Clinical PK/PD and safety in a randomized phase I clinical trial;Clinical and Translational Science;2024-02

4. Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase;Journal of Medicinal Chemistry;2023-11-28

5. Serum Proteomic Profiling in Patients with Chronic Obstructive Pulmonary Disease;International Journal of Chronic Obstructive Pulmonary Disease;2023-07

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