Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase-Reference-Cited by-同舟云学术

Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase

Published:2023-11-28 Issue:23 Volume:66 Page:16410-16425
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Thoma Gebhard¹^ORCID,Markert Christian¹^ORCID,Lueoend Rainer¹,Miltz Wolfgang¹,Spanka Carsten¹^ORCID,Bollbuck Birgit¹,Wolf Romain M.¹,Srinivas Honnappa²,Penno Carlos A.²,Kiffe Michael³,Gajewska Monika³,Bednarczyk Dallas⁴,Wieczorek Grazyna⁵,Evans Amanda⁵,Beerli Christian⁵,Röhn Till A.⁵

Affiliation:

1. Global Discovery Chemistry, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland

2. Chemical Biology & Therapeutics, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland

3. PK Sciences, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland

4. Discovery & Translational Lab, Biomedical Research, Novartis Pharma AG, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

5. Immunology Disease Area, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01866

Reference41 articles.

1. Leukotriene A4 Hydrolase/Aminopeptidase, the Gatekeeper of Chemotactic Leukotriene B4 Biosynthesis

2. Leukotrienes

3. Targeting leukotriene B4in inflammation

4. Leukotriene biosynthetic enzymes as therapeutic targets

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