Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase

Published:2023-11-28 Issue:23 Volume:66 Page:16410-16425
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Thoma Gebhard¹^ORCID,Markert Christian¹^ORCID,Lueoend Rainer¹,Miltz Wolfgang¹,Spanka Carsten¹^ORCID,Bollbuck Birgit¹,Wolf Romain M.¹,Srinivas Honnappa²,Penno Carlos A.²,Kiffe Michael³,Gajewska Monika³,Bednarczyk Dallas⁴,Wieczorek Grazyna⁵,Evans Amanda⁵,Beerli Christian⁵,Röhn Till A.⁵

Affiliation:

1. Global Discovery Chemistry, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland

2. Chemical Biology & Therapeutics, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland

3. PK Sciences, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland

4. Discovery & Translational Lab, Biomedical Research, Novartis Pharma AG, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

5. Immunology Disease Area, Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01866

Reference41 articles.

1. Leukotriene A4 Hydrolase/Aminopeptidase, the Gatekeeper of Chemotactic Leukotriene B4 Biosynthesis

2. Leukotrienes

3. Targeting leukotriene B4in inflammation

4. Leukotriene biosynthetic enzymes as therapeutic targets

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP