Thermodynamic profiling for fragment-based lead discovery and optimization
Author:
Affiliation:
1. Medicinal Chemistry Research Group, Research Center for Natural Sciences, Budapest, Hungary
Publisher
Informa UK Limited
Subject
Drug Discovery
Link
https://www.tandfonline.com/doi/pdf/10.1080/17460441.2020.1691166
Reference96 articles.
1. Enthalpic Efficiency of Ligand Binding
2. Thermodynamic Basis of Resistance to HIV-1 Protease Inhibition: Calorimetric Analysis of the V82F/I84V Active Site Resistant Mutant
3. HIV-1 Protease Inhibitors: Enthalpic versus Entropic Optimization of the Binding Affinity
4. Binding Thermodynamics of Statins to HMG-CoA Reductase
5. Do enthalpy and entropy distinguish first in class from best in class?
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