A high-resolution structural characterization and physicochemical study of how a peptoid binds to an oncoprotein MDM2-Reference-Cited by-同舟云学术

A high-resolution structural characterization and physicochemical study of how a peptoid binds to an oncoprotein MDM2

Published:2024 Issue:19 Volume:15 Page:7051-7060
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Yokomine Marin¹^ORCID,Morimoto Jumpei¹^ORCID,Fukuda Yasuhiro¹^ORCID,Ueda Takumi²^ORCID,Takeuchi Koh²^ORCID,Umezawa Koji³⁴,Ago Hideo⁵,Matsuura Hiroaki⁵,Ueno Go⁵,Senoo Akinobu¹,Nagatoishi Satoru⁶^ORCID,Tsumoto Kouhei¹⁶⁷^ORCID,Sando Shinsuke¹⁶^ORCID

Affiliation:

1. Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan

2. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

3. Department of Biomedical Engineering, Graduate School of Science and Technology, Shinshu University, 8304 Minami-Minowa, Kami-Ina, Nagano, 399-4598, Japan

4. Department of Biomolecular Innovation, Institute for Biomedical Sciences, Shinshu University, 8304 Minami-Minowa, Kami-Ina, Nagano, 399-4598, Japan

5. RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo, Hyogo, 679-5148, Japan

6. Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan

7. Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan

Abstract

How a peptoid binds to a protein was revealed by a co-crystal structure and systematic physicochemical studies.

Funder

Japan Agency for Medical Research and Development

Japan Science and Technology Agency

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Royal Society of Chemistry (RSC)