Anti-trypanosomatid structure-based drug design – lessons learned from targeting the folate pathway

Author:

Panecka-Hofman Joanna1ORCID,Poehner Ina2ORCID,Wade Rebecca C.345ORCID

Affiliation:

1. Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Warsaw, Poland

2. School of Pharmacy, University of Eastern Finland, Kuopio, Finland

3. Center for Molecular Biology (ZMBH), Heidelberg University, Heidelberg, Germany

4. Molecular and Cellular Modeling group, Heidelberg Institute for Theoretical Studies (HITS), Heidelberg, Germany

5. DKFZ-ZMBH Alliance and Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Heidelberg, Germany

Funder

European Union’s Seventh Framework Programme for research, technological development

Polish National Science Centre

Publisher

Informa UK Limited

Subject

Drug Discovery

Reference124 articles.

1. WHO. WHO - Trypanosomiasis, human African (sleeping sickness) [Internet]. 2022 [cited 2022 Jan 24]. Available from: https://www.who.int/news-room/fact-sheets/detail/trypanosomiasis-human-african-(sleeping-sickness)

2. WHO. WHO - Chagas disease (American trypanosomiasis) [Internet]. 2022 [cited 2022 Jan 24]. Available from: https://www.who.int/health-topics/chagas-disease

3. WHO. WHO - Leishmaniasis [Internet]. 2022 [cited 2022 Jan 24]. Available from: https://www.who.int/health-topics/leishmaniasis

4. Nifurtimox-Eflornithine Combination Therapy for Second-Stage Gambiense Human African Trypanosomiasis: Médecins Sans Frontières Experience in the Democratic Republic of the Congo

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