In silico strategies on prion pathogenic conversion and inhibition from PrPC

In silico strategies on prion pathogenic conversion and inhibition from PrPC–PrPSc

Published:2017-02-02 Issue:3 Volume:12 Page:241-248
ISSN:1746-0441
Container-title:Expert Opinion on Drug Discovery
language:en
Short-container-title:Expert Opinion on Drug Discovery

Author:

Pagadala Nataraj S.¹,Syed Khajamohiddin²,Bhat Rakesh¹

Affiliation:

1. Department of Medical Microbiology and Immunology, 6-020 Katz Group Centre, University of Alberta, Edmonton, Canada

2. Unit for Drug Discovery Research, Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein, South Africa

Publisher

Informa UK Limited

Subject

Drug Discovery

Link

https://www.tandfonline.com/doi/pdf/10.1080/17460441.2017.1287171

Reference79 articles.

1. Novel Proteinaceous Infectious Particles Cause Scrapie

2. Nobel Lecture: Prions

3. New Inhibitors of Scrapie-Associated Prion Protein Formation in a Library of 2,000 Drugs and Natural Products

4. Structural Clues to Prion Replication

5. Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Binding modes of potential anti-prion phytochemicals to PrPC structures in silico;Journal of Ayurveda and Integrative Medicine;2023-07

2. Experiment and molecular dynamics simulations reveal proanthocyanidin B2 and B3 can inhibit prion aggregation by different mechanisms;Journal of Biomolecular Structure and Dynamics;2023-05-05

3. Unraveling the Molecular Mechanism of Prion H2 C-Terminus Misfolding by Metadynamics Simulations;ACS Chemical Neuroscience;2020-02-05

4. Identifying Anti-prion Chemical Compounds Using a Newly Established Yeast High-Throughput Screening System;Cell Chemical Biology;2019-12

5. Structural insight into conformational change in prion protein by breakage of electrostatic network around H187 due to its protonation;Scientific Reports;2019-12