Unraveling the Molecular Mechanism of Prion H2 C-Terminus Misfolding by Metadynamics Simulations-Reference-Cited by-同舟云学术

Unraveling the Molecular Mechanism of Prion H2 C-Terminus Misfolding by Metadynamics Simulations

Published:2020-02-05 Issue:5 Volume:11 Page:772-782
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Xu Zerong¹,Liu Hongli¹,Wang Shuo¹,Zhang Qianqian¹,Yao Xiaojun²^ORCID,Zhou Shuangyan³^ORCID,Liu Huanxiang¹^ORCID

Affiliation:

1. School of Pharmacy, Lanzhou University, Lanzhou 730000, China

2. State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau, China

3. Chongqing Key Laboratory of Big Data for Bio Intelligence, Chongqing University of Posts and Telecommunications, Chongqing 400065, China

Funder

Chongqing Municipal Education Commission Foundation

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.9b00679

Reference60 articles.

1. Nobel Lecture: Prions

2. Prion disease genetics

3. In silico strategies on prion pathogenic conversion and inhibition from PrPC–PrPSc

4. Truncated prion protein PrP226* - A structural view on its role in amyloid disease

5. NMR solution structure of the human prion protein

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