Deciphering deamidation and isomerization in therapeutic proteins: Effect of neighboring residue
Author:
Affiliation:
1. Human Genetics Department, Genentech Inc, South San Francisco, United States
2. Pharmaceutical Development Department, Genentech Inc, South San Francisco, United States
Funder
funding
Publisher
Informa UK Limited
Subject
Immunology,Immunology and Allergy
Link
https://www.tandfonline.com/doi/pdf/10.1080/19420862.2022.2143006
Reference70 articles.
1. Biophysical properties of the clinical-stage antibody landscape
2. Five computational developability guidelines for therapeutic antibody profiling
3. Structure, heterogeneity and developability assessment of therapeutic antibodies
4. Deamidation of human proteins
5. Post-translational modifications in the context of therapeutic proteins
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2. Molecular Modeling of the Deamidation Reaction in Solution: A Theoretical–Computational Study;The Journal of Physical Chemistry B;2023-10-30
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