Discovery, characterization, and remediation of a C-terminal Fc-extension in proteins expressed in CHO cells
Author:
Affiliation:
1. Discovery Attribute Sciences, Therapeutic Discovery, Amgen Discovery Research, Thousand Oaks, CA, USA
2. Biologics Optimization, Therapeutic Discovery, Amgen Discovery Research, Thousand Oaks, CA, USA
Publisher
Informa UK Limited
Subject
Immunology,Immunology and Allergy
Link
https://www.tandfonline.com/doi/pdf/10.1080/19420862.2018.1511197
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4. High-resolution mass spectrometry confirms the presence of a hydroxyproline (Hyp) post-translational modification in the GGGGP linker of an Fc-fusion protein
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