How the Deuteration of Dronedarone Can Modify Its Cardiovascular Profile: In Vivo Characterization of Electropharmacological Effects of Poyendarone, a Deuterated Analogue of Dronedarone-Reference-Cited by-同舟云学术

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How the Deuteration of Dronedarone Can Modify Its Cardiovascular Profile: In Vivo Characterization of Electropharmacological Effects of Poyendarone, a Deuterated Analogue of Dronedarone

Published:2020-01-02 Issue:4 Volume:20 Page:339-350
ISSN:1530-7905
Container-title:Cardiovascular Toxicology
language:en
Short-container-title:Cardiovasc Toxicol

Author:

Kambayashi Ryuichi,Hagiwara-Nagasawa Mihoko,Kondo Yoshiki,Yeo Zhi Jie,Goto Ai,Chiba Koki,Nunoi Yoshio,Izumi-Nakaseko Hiroko,Leow Jacqueline Wen Hui,Venkatesan Gopalakrishnan,Matsumoto Akio,Chan Eric Chun Yong,Sugiyama Atsushi

Funder

Japan Society for the Promotion of Science

Singapore Ministry of Education

National University Heart Centre Singapore

Publisher

Springer Science and Business Media LLC

Subject

Cardiology and Cardiovascular Medicine,Toxicology,Molecular Biology

Link

http://link.springer.com/content/pdf/10.1007/s12012-019-09559-0.pdf

Reference34 articles.

1. Singh, B. N., Connolly, S. J., Crijns, H. J., Roy, D., Kowey, P. R., Capucci, A., et al. (2007). Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter. New England Journal of Medicine,357, 987–999.

2. Touboul, P., Brugada, J., Capucci, A., Crijns, J. G. M. H., Edvardsson, N., & Hohnloser, H. S. (1998). Dronedarone for prevention of atrial fibrillation: A dose-ranging study. European Heart Journal,19, 1294–1320.

3. Hohnloser, S. H., Crijns, H. J., van Eickels, M., Gaudin, C., Page, R. L., Torp-Pedersen, C., et al. (2009). Effect of dronedarone on cardiovascular events in atrial fibrillation [published correction appears in N Engl J Med. 2011;364:1481]. New England Journal of Medicine,360, 668–678.

4. Gautier, P., Guillemare, E., Marion, A., Bertrand, J. P., Tourneur, Y., & Nisato, D. (2003). Electrophysiologic characterization of dronedarone in guinea pig ventricular cells. Journal of Cardiovascular Pharmacology,41, 191–202.

5. Guillemare, E., Marion, A., Nisato, D., & Gautier, P. (2000). Inhibitory effects of dronedarone on muscarinic K+ current in guinea pig atrial cells. Journal of Cardiovascular Pharmacology,36, 802–805.

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1. Tandem Protocol for Diversified Deuteration of Secondary Aliphatic Amines under Mild Conditions;The Journal of Organic Chemistry;2024-08-05

2. Metabolic activation of drugs by cytochrome P450 enzymes: Biochemical insights into mechanism-based inactivation by fibroblast growth factor receptor inhibitors and chemical approaches to attenuate reactive metabolite formation;Biochemical Pharmacology;2022-12

3. Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts;Acta Pharmaceutica Sinica B;2022-10

4. Rational deuteration of dronedarone attenuates its toxicity in human hepatic HepG2 cells;Toxicology Research;2022-03-28

5. An exploratory analysis of effects of poyendarone, a deuterated analogue of dronedarone, on the canine model of paroxysmal atrial fibrillation;Naunyn-Schmiedeberg's Archives of Pharmacology;2021-01-11

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