Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts-Reference-Cited by-同舟云学术

Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts

Published:2022-10 Issue:10 Volume:12 Page:3905-3923
ISSN:2211-3835
Container-title:Acta Pharmaceutica Sinica B
language:en
Short-container-title:Acta Pharmaceutica Sinica B

Author:

Karkhanis Aneesh V.^ORCID,Venkatesan Gopalakrishnan^ORCID,Kambayashi Ryuichi,Leow Jacqueline Wen Hui,Han Marcus Qingrui^ORCID,Izumi-Nakaseko Hiroko,Goto Ai,Pang Jeremy Kah Sheng^ORCID,Soh Boon Seng^ORCID,Kojodjojo Pipin,Sugiyama Atsushi^ORCID,Chan Eric Chun Yong^ORCID

Publisher

Elsevier BV

Subject

General Pharmacology, Toxicology and Pharmaceutics

Reference80 articles.

1. P-450 metabolites of arachidonic acid in the control of cardiovascular function;Roman;Physiol Rev,2002

2. Detection of human CYP2C8, CYP2C9, and CYP2J2 in cardiovascular tissues;DeLozier;Drug Metab Dispos,2007

3. Metabolic activity and mRNA levels of human cardiac CYP450s involved in drug metabolism;Michaud;PLoS One,2010

4. Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart;Wu;J Biol Chem,1996

5. Inhibition and inactivation of human CYP2J2: implications in cardiac pathophysiology and opportunities in cancer therapy;Karkhanis;Biochem Pharmacol,2017

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