NLRP3 Inflammasome Inhibition Prevents α-Synuclein Pathology by Relieving Autophagy Dysfunction in Chronic MPTP–Treated NLRP3 Knockout Mice-Reference-Cited by-同舟云学术

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NLRP3 Inflammasome Inhibition Prevents α-Synuclein Pathology by Relieving Autophagy Dysfunction in Chronic MPTP–Treated NLRP3 Knockout Mice

Published:2020-11-09 Issue:4 Volume:58 Page:1303-1311
ISSN:0893-7648
Container-title:Molecular Neurobiology
language:en
Short-container-title:Mol Neurobiol

Author:

Ou Zhou,Zhou Yuanzhang,Wang Lijun,Xue Liujun,Zheng Jinlong,Chen Liam,Tong Qiang^ORCID

Funder

Young Scientists Fund

Basic Research Program of Jiangsu Province

Six Talent Peaks Project in Jiangsu Province

533 Talent Project of Huai'an City

Publisher

Springer Science and Business Media LLC

Subject

Neuroscience (miscellaneous),Cellular and Molecular Neuroscience,Neurology

Link

http://link.springer.com/content/pdf/10.1007/s12035-020-02198-5.pdf

Reference26 articles.

1. Hirsch EC, Vyas S, Hunot S (2012) Neuroinflammation in Parkinson's disease. Parkinsonism Relat Disord 18(Suppl 1):S210–S212

2. Heneka MT, McManus RM, Latz E (2018) Inflammasome signalling in brain function and neurodegenerative disease. Nat Rev Neurosci 19(10):610–621

3. Gordon R, Albornoz EA, Christie DC et al (2018) Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Sci Transl Med 10(465):eaah4066

4. Mao Z, Liu C, Ji S, Yang Q, Ye H, Han H, Xue Z (2017) The NLRP3 Inflammasome is involved in the pathogenesis of Parkinson's disease in rats. Neurochem Res 42(4):1104–1115

5. Sarkar S, Malovic E, Harishchandra DS, Ghaisas S, Panicker N, Charli A, Palanisamy BN, Rokad D et al (2017) Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. NPJ Parkinsons Dis 3:30

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