Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice-Reference-Cited by-同舟云学术

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

Published:2018-10-31 Issue:465 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Gordon Richard¹²^ORCID,Albornoz Eduardo A.¹³^ORCID,Christie Daniel C.¹^ORCID,Langley Monica R.⁴^ORCID,Kumar Vinod¹^ORCID,Mantovani Susanna²⁵^ORCID,Robertson Avril A. B.³⁶^ORCID,Butler Mark S.³^ORCID,Rowe Dominic B.⁷^ORCID,O’Neill Luke A.⁸,Kanthasamy Anumantha G.⁴^ORCID,Schroder Kate³^ORCID,Cooper Matthew A.³⁸^ORCID,Woodruff Trent M.¹

Affiliation:

1. School of Biomedical Sciences, Faculty of Medicine, University of Queensland, St Lucia, Queensland 4072, Australia.

2. UQ Centre for Clinical Research, Faculty of Medicine, University of Queensland, Herston, Queensland 4092, Australia.

3. Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland 4072, Australia.

4. Parkinson Disorders Research Program, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.

5. Department of Neurology, Royal Brisbane and Women’s Hospital, Herston, Queensland 4006, Australia.

6. School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia.

7. Department of Neurology, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.

8. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Dublin 2, Ireland.

Abstract

Oral treatment with a brain-penetrant NLRP3 inhibitor has protective effects in preclinical models of Parkinson’s disease.

Funder

Michael J. Fox Foundation for Parkinson’s Research

Australian Research Council

National Health and Medical Research Council

Department of Science, Information Technology and Innovation, Queensland Government

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference39 articles.

1. Parkinson disease

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