Piperazine ring toxicity in three novel anti-breast cancer drugs: an in silico and in vitro metabolic bioactivation approach using olaparib as a case study-Reference-Cited by-同舟云学术

Piperazine ring toxicity in three novel anti-breast cancer drugs: an in silico and in vitro metabolic bioactivation approach using olaparib as a case study

Published:2023-02-04 Issue:7 Volume:396 Page:1435-1450
ISSN:0028-1298
Container-title:Naunyn-Schmiedeberg's Archives of Pharmacology
language:en
Short-container-title:Naunyn-Schmiedeberg's Arch Pharmacol

Author:

Alsubi Thamer A.,Attwa Mohamed W.,Darwish Hany W.,Abuelizz Hatem A.,Kadi Adnan A.

Funder

The Deputyship for Research & Innovation, “Ministry of Education” in Saudi Arabia

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,General Medicine

Link

https://link.springer.com/content/pdf/10.1007/s00210-023-02413-9.pdf

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2. Alhoshani A, Alanazi FE, Alotaibi MR, Attwa MW, Kadi AA, Aldhfyan A, Akhtar S, Hourani S, Agouni A, Zeidan A, Korashy HM (2020) EGFR inhibitor gefitinib induces cardiotoxicity through the modulation of cardiac PTEN/Akt/FoxO3a pathway and reactive metabolites formation: in vivo and in vitro rat studies. Chem Res Toxicol 33:1719–1728

3. Alsubi TA, Attwa MW, Bakheit AH, Darwish HW, Abuelizz HA, Kadi AA (2020) In silico and in vitro metabolism of ribociclib: a mass spectrometric approach to bioactivation pathway elucidation and metabolite profiling. RSC Adv 10:22668–22683

4. Argoti D, Liang L, Conteh A, Chen L, Bershas D, Yu C-P, Vouros P, Yang E (2005) Cyanide trapping of iminium ion reactive intermediates followed by detection and structure identification using liquid chromatography−tandem mass spectrometry (LC-MS/MS). Chem Res Toxicol 18:1537–1544

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