EGFR Inhibitor Gefitinib Induces Cardiotoxicity through the Modulation of Cardiac PTEN/Akt/FoxO3a Pathway and Reactive Metabolites Formation: In Vivo and in Vitro Rat Studies-Reference-Cited by-同舟云学术

EGFR Inhibitor Gefitinib Induces Cardiotoxicity through the Modulation of Cardiac PTEN/Akt/FoxO3a Pathway and Reactive Metabolites Formation: In Vivo and in Vitro Rat Studies

Published:2020-05-06 Issue:7 Volume:33 Page:1719-1728
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Alhoshani Ali¹,Alanazi Fawaz E.¹²,Alotaibi Moureq R.¹,Attwa Mohamed W.³⁴^ORCID,Kadi Adnan A.³,Aldhfyan Abdullah⁵,Akhtar Sabah⁶,Hourani Shireen⁶,Agouni Abdelali⁶,Zeidan Asad⁷,Korashy Hesham M.⁶^ORCID

Affiliation:

1. Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia

2. Security Forces Hospital Program, P.O. Box 3643, Riyadh 11481, Saudi Arabia

3. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia

4. Students’ University Hospital, Mansoura University, Mansoura 35516, Egypt

5. Stem Cell & Tissue Re-Engineering, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia

6. Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar

7. College of Medicine, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar

Funder

King Abdulaziz City for Science and Technology

Publisher

American Chemical Society (ACS)