Identification and characterization of in silico, in vivo, in vitro, and reactive metabolites of infigratinib using LC-ITMS: bioactivation pathway elucidation and in silico toxicity studies of its metabolites-Reference-Cited by-同舟云学术

Identification and characterization of in silico, in vivo, in vitro, and reactive metabolites of infigratinib using LC-ITMS: bioactivation pathway elucidation and in silico toxicity studies of its metabolites

Published:2020 Issue:28 Volume:10 Page:16231-16244
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Al-Shakliah Nasser S.¹²³⁴¹,Attwa Mohamed W.¹²³⁴⁵^ORCID,Kadi Adnan A.¹²³⁴,AlRabiah Haitham¹²³⁴

Affiliation:

1. Department of Pharmaceutical Chemistry

2. College of Pharmacy

3. King Saud University

4. Saudi Arabia

5. Students' University Hospital

Abstract

An in silico web designer tool was utilized to guide laboratory work for infigratinib metabolism. Sixteen metabolites of infigratinib and seven reactive intermediates (three iminium ions and four 1,4 benzoquinones) were characterized using LC-ITMS.

Funder

King Saud University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/C9RA10871H

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