Identification of the human Cytochrome P450 enzymes (P450s) responsible for metabolizing infigratinib to its pharmacologically active Metabolites, BHS697, and CQM157, and assessment of their in vitro inhibition of P450s and UDP-glucuronosyltransferases (UGTs)-Reference-Cited by-同舟云学术

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Identification of the human Cytochrome P450 enzymes (P450s) responsible for metabolizing infigratinib to its pharmacologically active Metabolites, BHS697, and CQM157, and assessment of their in vitro inhibition of P450s and UDP-glucuronosyltransferases (UGTs)

Published:2024-08 Issue: Volume:226 Page:116390
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Liu Shuaibing,Zhao Shiyu,Zhang XueXia,Chun Yong Chan Eric,Wang Ziteng,Li Hang,Tian Xin

Publisher

Elsevier BV

Reference16 articles.

1. Phase II study of BGJ398 in patients with FGFR-altered advanced cholangiocarcinoma;Javle;J. Clin. Oncol.,2018

2. Infigratinib (BGJ398): an investigational agent for the treatment of FGFR-altered intrahepatic cholangiocarcinoma;Botrus;Expert Opin. Invest. Drugs,2021

3. A. UFD, FDA grants accelerated approval to infgratinib for metastatic cholangiocarcinoma, 2021.

4. Infigratinib: first approval;Kang;Drugs,2021

5. Q.T. I, TRUSELTIQ (infgratinib) Multi-Discipline Review Files, 2021. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2021/214622Orig1s000MultidisciplineR.pdf.

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