Fasudil promotes polyploidization of megakaryoblasts in an acute megakaryocyte leukemia model
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology,General Medicine
Link
https://link.springer.com/content/pdf/10.1007/s00210-023-02513-6.pdf
Reference25 articles.
1. Avanzi MP, Goldberg F, Davila J et al (2014) Rho kinase inhibition drives megakaryocyte polyploidization and proplatelet formation through MYC and NFE2 downregulation. Br J Haematol 164:867–876
2. Boyle ST, Poltavets V, Kular J et al (2020) ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism. Nat Cell Biol 22:882–895
3. De Rooij JDE, Branstetter C, Ma J et al (2017) Pediatric non-down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes. Nat Genet 49:451
4. Du R, Huang C, Liu K et al (2021) Targeting AURKA in cancer: molecular mechanisms and opportunities for Cancer therapy. Mol Cancer 20:15
5. Gangat N, Marinaccio C, Swords R et al (2019) Aurora kinase A inhibition provides clinical benefit, normalizes megakaryocytes, and reduces bone marrow fibrosis in patients with myelofibrosis: a phase I trial. Clin Cancer Res 25:4898–4906
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