Paradoxes and paradigms: are maleimides antiaromatic, aromatic, or neither?

Author:

Ptaszek MarcinORCID,Liebman Joel FredricORCID

Funder

National Science Foundation

Publisher

Springer Science and Business Media LLC

Subject

Physical and Theoretical Chemistry,Condensed Matter Physics

Reference54 articles.

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2. Wagner J, von Matt SR, Albert R, Cooke N, Ehrhardt C, Geiser M, Rummel G, Stark W, Strauss A, Cowan-Jacob SW, Beerli C, Weckbecker G, Evanou JP, Zenke G, Cottens S (2009) Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]-pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes. J Med Chem 52:6193–6196. https://doi.org/10.1021/jm901108b

3. Gunosewoyo H, Midzak A, Gaisina IN, Sabath EV, Fedolak A, Hanania T, Brunner D, Papadopoulos V, Kozikowski AP (2013) Characterization of maleimide-based glycogen synthase kinase-3(GSK-3) inhibitors as stimulators of stereoidogenesis. J Med Chem 56:5115–5129. https://doi.org/10.1021/jm400511s

4. Zhang M, Li B, Chen H, Lu H, Ma H, Cheng X, Wang W, Wang Y, Ding Y, Hu A (2020) Triggering the antitumor activity of acyclic enediyne through maleimide-assisted rearrangement and cycloaromatization. J Org Chem 85:9808–9819. https://doi.org/10.1021/acs.joc.0c01124

5. Chen Y, Tsao K, Acton SL, Keillor JW (2018) A green BODIPY-based, super-fluorogenic, protein-specific labelling agent. Angew Chem Int Ed 57:12390–12394. https://doi.org/10.1002/anie.201805482

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