Shear conditions in clavulanic acid production by Streptomyces clavuligerus in stirred tank and airlift bioreactors
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Medicine,Bioengineering,Biotechnology
Link
http://link.springer.com/content/pdf/10.1007/s00449-012-0682-8.pdf
Reference28 articles.
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2. Mayer AF, Deckwer WD (1996) Simultaneous production and decomposition of clavulanic acid during Streptomyces clavuligerus cultivations. Appl Microbiol Biotechnol 45:41–46
3. Roubos JA, Krabben P, Luiten RGM, Verbruggen HB, Heijnen JJ (2001) A quantitative approach to characterizing cell lysis caused by mechanical agitation of Streptomyces clavuligerus. Biotechnol Progr 17:336–347
4. Rosa JC, Baptista-Neto A, Hokka CO, Badino AC (2005) Influence of dissolved oxygen and shear conditions on clavulanic acid production by Streptomyces clavuligerus. Bioprocess Biosyst Eng 27:99–104
5. Teodoro JC, Baptista-Neto A, Cruz-Hernández IL, Hokka CO, Badino AC (2006) Influence of feeding conditions on clavulanic acid production in fed-batch cultivation with medium containing glycerol. Appl Microbiol Biotechnol 72:450–455
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