Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Organic Chemistry,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biotechnology
Link
http://link.springer.com/article/10.1007/s11095-017-2246-8/fulltext.html
Reference37 articles.
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5. Kim S, Dinchuk JE, Anthony MN, Orcutt T, Zoeckler ME, Sauer MB, et al. Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction. Drug Metab Dispos. 2010;38(1):16–24.
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