A Semi-Physiologically Based Pharmacokinetic Model Describing the Altered Metabolism of Midazolam Due to Inflammation in Mice-Reference-Cited by-同舟云学术

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A Semi-Physiologically Based Pharmacokinetic Model Describing the Altered Metabolism of Midazolam Due to Inflammation in Mice

Published:2018-06-21 Issue:8 Volume:35 Page:
ISSN:0724-8741
Container-title:Pharmaceutical Research
language:en
Short-container-title:Pharm Res

Author:

Varkhede Ninad,Patel Nita,Chang William,Ruterbories Kenneth,Laird Forrest M.

Funder

Eli Lilly and Company

National Institutes of Health

University of Kansas, Higuchi Fellowship

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Organic Chemistry,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biotechnology

Link

http://link.springer.com/article/10.1007/s11095-018-2447-9/fulltext.html

Reference47 articles.

1. Morgan E. Impact of infectious and inflammatory disease on cytochrome P450–mediated drug metabolism and pharmacokinetics. Clin Pharmacol Ther. 2009;85(4):434–8.

2. Frye RF, Schneider VM, Frye CS, Feldman AM. Plasma levels of TNF-α and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure. J Card Fail. 2002;8(5):315–9.

3. Coutant D, Kulanthaivel P, Turner P, Bell R, Baldwin J, Wijayawardana S, et al. Understanding disease–drug interactions in Cancer patients: implications for dosing within the therapeutic window. Clin Pharmacol Ther. 2015;98(1):76–86.

4. Robertson G, Liddle C, Clarke S. Inflammation and altered drug clearance in Cancer: transcriptional repression of a human CYP3A4 transgene in tumor-bearing mice. Clin Pharmacol Ther. 2008;83(6):894–7.

5. Aitken AE, Morgan ET. Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes. Drug Metab Disposition. 2007;35(9):1687–93.

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