Variability in Human In Vitro Enzyme Kinetics

Author:

Gibson Christopher R.,Wang Ying-Hong,Varkhede Ninad,Ma Bennett

Publisher

Springer US

Reference157 articles.

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2. Gomez-Lechon MJ, Castell JV, Donato MT (2007) Hepatocytes—the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo. Chem Biol Interact 168(1):30–50

3. Rowland-Yeo K (2004) Abundance of cytochromes P450 in human liver: a meta-analysis. Br J Clin Pharmacol 57:687

4. Hallifax D, Houston J (2009) Methodological uncertainty in quantitative prediction of human hepatic clearance from in vitro experimental systems. Curr Drug Metab 10(3):307–321

5. Gomez-Lechon M, Donato M, Castell J et al (2004) Human hepatocytes in primary culture: the choice to investigate drug metabolism in man. Curr Drug Metab 5(5):443–462

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