NIX protein enhances antioxidant capacity of and reduces the apoptosis induced by HSP90 inhibitor luminespib/NVP-AUY922 in PC12 cells

Author:

Zhang Hong,Ge Fanghui,Shui Xindong,Xiang Yuling,Wang Xinxin,Liao Chang,Wang JiandongORCID

Funder

Application Foundation Research Project of Sichuan Provincial Department of Science and Technology

Scientific Research Foundation of the Education Department of Sichuan Province, China

Collaborative Innovation Center of Sichuan for Elderly Care and Health, Chengdu Medical College

Innovation and entrepreneurship training program for College Students, Chengdu Medical College

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Biochemistry

Reference23 articles.

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2. Drake LE, Springer MZ, Poole LP, Kim CJ, Macleod KF (2017) Expanding perspectives on the significance of mitophagy in cancer. Semin Cancer Biol 47:110–124. https://doi.org/10.1016/j.semcancer.2017.04.008

3. Graner AN, Hellwinkel JE, Lencioni AM, Madsen HJ, Harland TA, Marchando P, Nguyen GJ, Wang M, Russell LM, Bemis LT, Anchordoquy TJ, Graner MW (2017) HSP90 inhibitors in the context of heat shock and the unfolded protein response: effects on a primary canine pulmonary adenocarcinoma cell line. Int J Hyperth 33:303–317. https://doi.org/10.1080/02656736.2016.1256503

4. Hansen M, Porosk R, Mahlapuu R, Kairane C, Kilk K, Soomets U (2019) GSH synthetic analogue O-methyl-L-tyrosinylglutathione regulates Nrf2-mediated expression of GCLc and GCLm. J Chem 2019:1–9. https://doi.org/10.1155/2019/3841219

5. Humpton TJ, Alagesan B, Denicola GM, Lu D, Yordanov GN, Leonhardt CS, Yao MA, Alagesan P, Zaatari MN, Park Y, Skepper JN, Macleod KF, Perez-Mancera PA, Murphy MP, Evan GI, Vousden KH, Tuveson DA (2019) Oncogenic KRAS induces NIX-mediated mitophagy to promote pancreatic cancer. Cancer Discov 9:1268–1287. https://doi.org/10.1158/2159-8290.CD-18-1409

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