Synthesis and biological evaluation of xanthone derivatives as anti-cancer agents targeting topoisomerase II and DNA-Reference-Cited by-同舟云学术

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Synthesis and biological evaluation of xanthone derivatives as anti-cancer agents targeting topoisomerase II and DNA

Published:2022-03-12 Issue:5 Volume:31 Page:720-734
ISSN:1054-2523
Container-title:Medicinal Chemistry Research
language:en
Short-container-title:Med Chem Res

Author:

Song Yali,Zhu Xinyue,Yang Kan,Feng Siran,Zhang Yiwen,Dong Jinjiao,Liu Zhenming,Qiao Xiaoqiang

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Link

https://link.springer.com/content/pdf/10.1007/s00044-022-02862-6.pdf

Reference45 articles.

1. Jaracz S, Chen J, Kuznetsova LV, Ojima I. Recent advances in tumor-targeting anticancer drug conjugates. Bioorg Medicinal Chem. 2005;13:5043–54. https://doi.org/10.1016/j.bmc.2005.04.084.

2. Li PH, Zeng P, Chen SB, Yao PF, Mai YW, Tan JH. et al. Synthesis and mechanism studies of 1,3-benzoazolyl substituted pyrrolo[2,3-b]pyrazine derivatives as nonintercalative topoisomerase ii catalytic inhibitors. J Med Chem. 2016;59:238–52. https://doi.org/10.1021/acs.jmedchem.5b01284.

3. Sangpheak K, Mueller M, Darai N, Wolschann P, Suwattanasophon C, Ruga R. et al. Computational screening of chalcones acting against topoisomerase IIα and their cytotoxicity towards cancer cell lines. J Enzym inhibition medicinal Chem. 2019;34:134–43. https://doi.org/10.1080/14756366.2018.1507029.

4. Sheng J, Gan J, Huang Z. Structure-based DNA-targeting strategies with small molecule ligands for drug discovery. Medicinal Res Rev. 2013;33:1119–73. https://doi.org/10.1002/med.21278.

5. Deady LW, Kaye AJ, Finlay GJ, Baguley BC, Denny WA. Synthesis and antitumor properties ofN-[2-(dimethylamino)ethyl]carboxamide derivatives of fused tetracyclic quinolines and quinoxalines: anew class of putative topoisomerase inhibitors. J Med Chem. 1997;40:2040–6. https://doi.org/10.1021/jm970044r.

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