Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors-Reference-Cited by-同舟云学术

Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors

Published:2015-12-21 Issue:1 Volume:59 Page:238-252
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Peng-Hui¹,Zeng Ping¹,Chen Shuo-Bin¹,Yao Pei-Fen¹,Mai Yan-Wen¹,Tan Jia-Heng¹,Ou Tian-Miao¹,Huang Shi-Liang¹,Li Ding¹,Gu Lian-Quan¹,Huang Zhi-Shu¹

Affiliation:

1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People’s Republic of China

Funder

Ministry of Education of the People's Republic of China

National Natural Science Foundation of China

Guangdong Provincial Key Laboratory of Construction Foundation, Sun Yat-sen University

Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01284

Reference48 articles.

1. Contemporary Challenges in the Design of Topoisomerase II Inhibitors for Cancer Chemotherapy

2. DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition

3. Drugging Topoisomerases: Lessons and Challenges

4. Targeting DNA topoisomerase II in cancer chemotherapy

5. All tangled up: how cells direct, manage and exploit topoisomerase function

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