Affiliation:
1. Laboratory of Catalysis and Synthesis in Organic Chemistry, Faculty of Sciences, University of Tlemcen, BP 119, 13000 Tlemcen,
Algeria
2. Faculty of Sciences and Technology, Belhadj Bouchaib University of Ain Témouchent, 46000 Ain Témouchent, B.P 284,
Algeria
Abstract
Abstract:
Nitrogen heterocycles represent one of the most important units in modern organic
chemistry besides their wide existence broadly in natural products, pharmaceuticals, and
functional materials. Among these heterocycles, pyrazole, the molecule of the present work,
received much attention in organic synthesis because it delivers significant therapeutic and
biological values as it was found to be the core unit of many drugs, agrochemicals, and related
candidates. Due to this fact, the development of practical methodologies for the preparation
of pyrazoles has attracted the long-standing interest of synthetic chemists. Synthetic heterocyclic
chemistry using green methods has captivated many researchers in the recent past
due to its easy operation and environmentally friendliness. In this review, we summarized
systematic approaches for the synthesis of pyrazole derivatives via heterogeneous catalysis,
ionic liquid catalysis, and multicomponent reactions.
Publisher
Bentham Science Publishers Ltd.