Computational screening of chalcones acting against topoisomerase IIα and their cytotoxicity towards cancer cell lines

Author:

Sangpheak Kanyani1,Mueller Monika2,Darai Nitchakan1,Wolschann Peter23,Suwattanasophon Chonticha2,Ruga Ritbey4,Chavasiri Warinthon4,Seetaha Supaporn5,Choowongkomon Kiattawee5,Kungwan Nawee67,Rungnim Chompoonut8,Rungrotmongkol Thanyada910

Affiliation:

1. Faculty of Science, Program in Biotechnology, Chulalongkorn University, Bangkok, Thailand;

2. Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Vienna, Austria;

3. Institute of Theoretical Chemistry, University of Vienna, Vienna, Austria;

4. Faculty of Science, Center of Excellence in Natural Products Chemistry, Department of Chemistry, Chulalongkorn University, Bangkok, Thailand;

5. Faculty of Science, Department of Biochemistry, Kasetsart University, Bangkok, Thailand;

6. Faculty of Science, Department of Chemistry, Chiang Mai University, Chiang Mai, Thailand;

7. Center of Excellence in Materials Science and Technology, Chiang Mai University, Chiang Mai, Thailand;

8. Nanoscale Simulation Laboratory, National Nanotechnology Center, National Science and Technology Development Agency, Pathum Thani, Thailand;

9. Faculty of Science, Biocatalyst and Environmental Biotechnology Research Unit, Department of Biochemistry, Chulalongkorn University, Bangkok, Thailand;

10. Faculty of Science, Ph.D. Program in Bioinformatics and Computational Biology, Chulalongkorn University, Bangkok, Thailand

Funder

Thailand Research Fund

Thailand Graduate Institute of Science and Technology

Chulalongkorn University.

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Reference66 articles.

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