Ligand-based pharmacophore exploration and QSAR analysis of transition state analogues followed by in silico screening guide the discovery of new sub-micromolar β-secreatase inhibitors-Reference-Cited by-同舟云学术

Ligand-based pharmacophore exploration and QSAR analysis of transition state analogues followed by in silico screening guide the discovery of new sub-micromolar β-secreatase inhibitors

Published:2012-08-24 Issue:4 Volume:22 Page:1979-1997
ISSN:1054-2523
Container-title:Medicinal Chemistry Research
language:en
Short-container-title:Med Chem Res

Author:

Al-Nadaf Afaf,Taha Mutasem O.

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Link

http://link.springer.com/content/pdf/10.1007/s00044-012-0204-x.pdf

Reference66 articles.

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3. Abu Khalaf R, Abu Sheikha G, Bustanji Y, Taha MO (2010) Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic exploration. Eur J Med Chem 45:1598–1617

4. Abu Khalaf R, Abu Sheikha G, Bustanji Y, Taha MO (2011) Discovery of new β-D-glucosidase inhibitors via pharmacophore modeling and QSAR analysis followed by in silico screening. J Mol Model 17:443–464

5. Accelrys, Inc. (2005) CERIUS2, version 4.10 QSAR Users’ Manual. Accelrys, Inc, San Diego, pp 221–235

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