Discovery of new Gyrase β inhibitors via structure based modeling

Author:

Al-Nadaf Afaf H.,Salah Sajeda A.,Taha Mutasem O.ORCID

Publisher

Elsevier BV

Subject

Computational Mathematics,Organic Chemistry,Biochemistry,Structural Biology

Reference28 articles.

1. Ligand-based pharmacophore exploration and QSAR analysis of transition state analogues followed by in silico screening guide the discovery of new sub-micromolar b-secreatase inhibitors;Al-Nadaf;Med. Chem. Res.,2012

2. Discovery of new nanomolar peroxisome proliferator-activated receptor g activators via elaborate ligand-basedmodeling;Al-Najjar;Eur. J. Med. Chem.,2011

3. In silico discovery of 2-amino-4-(2, 4-dihydroxyphenyl)thiazoles as novel inhibitors of DNA gyrase B;Brvar;Bioorg. Med. Chem. Lett.,2010

4. In silico discovery and biophysical evaluation of novel 5-(2-hydroxybenzylidene) rhodanine inhibitors of DNA gyrase B;Brvar;Bioorg. Med. Chem.,2012

5. Structure-Based discovery of substituted 4, 5′-Bithiazoles as novel DNA gyrase inhibitors;Brvar;J. Med. Chem.,2012

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