Cytotoxicity of some synthetic bis(arylidene) derivatives of cyclic ketones towards cisplatin-resistant human ovarian carcinoma cells-Reference-Cited by-同舟云学术

Cytotoxicity of some synthetic bis(arylidene) derivatives of cyclic ketones towards cisplatin-resistant human ovarian carcinoma cells

Published:2020-04-17 Issue:6 Volume:29 Page:935-941
ISSN:1054-2523
Container-title:Medicinal Chemistry Research
language:en
Short-container-title:Med Chem Res

Author:

Patel Hinal,Mothia Begum,Patel Jaison,Fasanya Olatunde,Sooda Kartheek,Javid Farideh,Wyatt Peter B.

Abstract

AbstractSymmetrical α,αʹ-bis(arylidene)ketones were prepared by acid-catalyzed aldol condensations between aliphatic ketones (e.g., cyclopentanone, 4-alkylcyclohexanones, tetrahydropyran-4-one, and tetrahydrothiopyran-4-one) and two equivalents of an aromatic hydroxyaldehyde (e.g., 4-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, vanillin, isovanillin, and 3-fluoro-4-hydroxybenzaldehyde). Most of the compounds were cytotoxic towards the cisplatin-resistant human ovarian cancer cell line A2780-CP70 as well as the non-resistant line A2780.

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Link

https://link.springer.com/content/pdf/10.1007/s00044-020-02532-5.pdf

Reference18 articles.

1. Adams BK, Ferstl EM, Davis MC, Herold M, Kurtkayer S, Camalier RF, Hollingshead MG, Kaur G, Sausville EA, Rickles FR, Snyder JP, Liotta DC, Shoji M (2004) Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents. Bioorg Med Chem 12:3871–3883

2. Artico M, Di Santo R, Costi R, Novellino E, Greco G, Massa S, Tramontano E, Marongiu ME, De Montis A, La Colla P (1998) Geometrically and conformationally restrained cinnamoyl-compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation and molecular modeling. J Med Chem 41:3948–3960

3. Bairam R, Muppavarapu S, Sreekanth S (2017) Synthesis, characterization, biological evaluation and docking of some novel substituted 1,3-thiazine derivatives. Int J Pharm Pharm Sci 9:233–242

4. Cory S, Adams JM (2002) The BCL family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2:647–656

5. Costi R, Di Santo R, Artico M, Massa S, Ragno R, Loddo R, La Colla M, Tramontano E, La Colla P, Pani A (2004) 2,6-Bis(3,4,5-trihydroxybenzylydene) derivatives of cyclohexanone: novel potent HIV-1 integrase inhibitors that prevent HIV-1 multiplication in cell-based assays. Bioorg Med Chem 12:199–215

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Palladium decorated carbon nitride: A pragmatic catalyst for the construction of carbon-carbon double bonds in water;Journal of Molecular Structure;2024-03

2. Condensation of 3,5-Dialkyltetrahydro-4H-thiopyran-4-ones with Formaldehyde;Russian Journal of General Chemistry;2022-09

3. Exploration of structural, electronic and third order nonlinear optical properties of crystalline chalcone systems: Monoarylidene and unsymmetrical diarylidene cycloalkanones;Journal of Molecular Structure;2021-10

4. Tailored Functionalization of Natural Phenols to Improve Biological Activity;Biomolecules;2021-09-07