The Bcl2 family: regulators of the cellular life-or-death switch

Author:

Cory Suzanne,Adams Jerry M.

Publisher

Springer Science and Business Media LLC

Subject

General Earth and Planetary Sciences,General Environmental Science

Reference154 articles.

1. Kerr, J. F. R., Wyllie, A. H. & Currie, A. R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239–257 (1972).Cell death recognized to be an intrinsic cellular programme that plays a complementary role to mitosis in regulating tissue homeostasis.

2. Vaux, D. L., Cory, S. & Adams, J. M. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-Myc to immortalize pre-B cells. Nature 335, 440–442 (1988).Discovery that Bcl2 promotes cell survival. First recognition that cell survival is controlled separately from cell proliferation and that inhibition of apoptosis is a central step in tumour development. The first demonstration of co-operativity of Bcl2 and Myc in transformation.

3. Cory, S., Vaux, D. L., Strasser, A., Harris, A. W. & Adams, J. M. Insights from Bcl2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation. Cancer Res. 59, S1685–S1692 (1999).

4. Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell 100, 57–70 (2000).

5. Green, D. R. & Evan, G. I. A matter of life and death. Cancer Cell 1, 19–30 (2002).

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