Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21 Cip-Reference-Cited by-同舟云学术

Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21 Cip

Published:2012-02-12 Issue:5 Volume:55 Page:1380-1389
ISSN:0012-186X
Container-title:Diabetologia
language:en
Short-container-title:Diabetologia

Author:

Blandino-Rosano M.,Alejandro E. U.,Sathyamurthy A.,Scheys J. O.,Gregg B.,Chen A. Y.,Rachdi L.,Weiss A.,Barker D. J.,Gould A. P.,Elghazi L.,Bernal-Mizrachi E.

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00125-012-2465-9.pdf

Reference49 articles.

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3. Ueki K, Okada T, Hu J et al (2006) Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nat Genet 38:583–588

4. Okada T, Liew CW, Hu J et al (2007) Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci USA 104:8977–8982

5. Hugl SR, White MF, Rhodes CJ (1998) Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells. J Biol Chem 273:17771–17779

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