Novel roles of mTORC2 in regulation of insulin secretion by actin filament remodeling-Reference-Cited by-同舟云学术

Novel roles of mTORC2 in regulation of insulin secretion by actin filament remodeling

Published:2022-08-01 Issue:2 Volume:323 Page:E133-E144
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Blandino-Rosano Manuel¹^ORCID,Scheys Joshua O.²,Werneck-de-Castro Joao Pedro¹^ORCID,Louzada Ruy A.¹^ORCID,Almaça Joana¹,Leibowitz Gil³^ORCID,Rüegg Markus A.⁴^ORCID,Hall Michael N.⁴^ORCID,Bernal-Mizrachi Ernesto¹⁵^ORCID

Affiliation:

1. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida

2. Medical School, Division of Metabolism, Endocrinology, and Diabetes and Brehm Center for Diabetes Research, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan

3. Diabetes Unit and Endocrine Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

4. Biozentrum, University of Basel, Basel, Switzerland

5. Miami VA Healthcare System, Miami, Florida

Abstract

The current studies uncover a novel mechanism linking mTORC2 signaling to glucose-stimulated insulin secretion by modulation of the actin filaments. This work also underscores the important role of GLP-1 in rescuing defects in insulin secretion by modulating actin polymerization and suggests that this effect is independent of mTORC2 signaling.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00076.2022

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