Mechanistic incorporation of FcRn binding in plasma and endosomes in a whole body PBPK model for large molecules
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology
Link
https://link.springer.com/content/pdf/10.1007/s10928-023-09849-9.pdf
Reference23 articles.
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2. Abdiche YN, Yeung YA, Chaparro-Riggers J et al (2015) The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity. MAbs 7:331–343. https://doi.org/10.1080/19420862.2015.1008353
3. Igawa T, Maeda A, Haraya K et al (2013) Engineered monoclonal antibody with novel antigen-sweeping activity in vivo. PLOS ONE 8:e63236. https://doi.org/10.1371/journal.pone.0063236
4. Niederalt C, Kuepfer L, Solodenko J et al (2018) A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim. J Pharmacokinet Pharmacodyn 45:235–257. https://doi.org/10.1007/s10928-017-9559-4
5. Lee C-H, Kang TH, Godon O et al (2019) An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence. Nat Commun 10:5031. https://doi.org/10.1038/s41467-019-13108-2
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