Methyl gallate, methyl-3,4,5-trihydroxy-benzoate, is a potent and highly specific inhibitor of herpes simplex virus in vitro. I. Purification and characterization of methyl gallate from Sapium sebiferum-Reference-Cited by-同舟云学术

Methyl gallate, methyl-3,4,5-trihydroxy-benzoate, is a potent and highly specific inhibitor of herpes simplex virus in vitro. I. Purification and characterization of methyl gallate from Sapium sebiferum

Published:1988-02-01 Issue:1 Volume:8 Page:85-94
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Kane Cynthia J. M.¹²,Menna Jay H.³,Yeh Yun-Chi¹

Affiliation:

1. Department of Biochemistry & Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205

2. Department of Dermatology (R132) and Department of Biological Sciences, Stanford University, Stanford, CA 94305

3. Department of Microbiology & Immunology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205

Abstract

A potent anti-herpetic compound was identified and purified to homogeneity from the leaves of Sapium sebiferum by plaque reduction assay using herpes simplex virus type 2. The chemical structure of the purified compound was determined by mass spectroscopy and proton and carbon-13 nuclear magnetic resonance as methyl gallate, methyl-3,4,5-trihydroxybenzoate. This is the first demonstration that methyl gallate is a potent anti-herpetic compound in vitro, present in high concentration in the leaves of S. sebiferum, a Chinese folk medicine for shingles.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/8/1/85/472159/bsr0080085.pdf

Reference20 articles.

1. Barron, A. L., Olshevsky, C. and Cohen, M. M. (1970).Arch. Gesamte Virsuforsch. 32: 389?392.

2. Kane, C. J. M., Menna, J. H., Sung, C. C. and Yeh, Y. C. (1988).Biosci. Rep. 8:95?102.

3. Levy, G. C. and Nelson, G. L. (1972).Carbon-13 Nuclear Magnetic Resonance for Organic Chemists (John Wiley & Sons, Inc. New Yor, NY) p. 81

4. Haddock, E. A., Gupta, R. K., Al-Shafi, S. M. K. and Haslam, E. (1982).J. Chem. Soc. Perkin Trans. 1:2515?2524.

5. Patra, A. and Mukhopadhyay, P. K. (1983).J. Indian Chem. Soc. 60:265?268.

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