Convenient Synthesis of Ellagic Acid from Methyl Gallate and SARS-CoV-2 3CLpro Antiviral Activity-Reference-Cited by-同舟云学术

Convenient Synthesis of Ellagic Acid from Methyl Gallate and SARS-CoV-2 3CLpro Antiviral Activity

Published:2022-09-12 Issue:04 Volume:55 Page:657-662
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Pujol M. Dolors¹^ORCID,Navarro Francesc¹,Hamri Salha¹,Reches Rosa¹,Viñas Miquel¹,Jahani Daniel¹,Ginard Jaume¹,Vilardell Josep¹,Abián Olga²

Affiliation:

1. Laboratori de Química Farmacèutica, Facultat de Farmàcia, Universitat de Barcelona

2. Dpt. Bioquímica/IUI BIFI, Mariano-Esquillor, Edificio I+D Campus Río Ebro, Universidad de Zaragoza

Abstract

AbstractA practical synthesis of ellagic acid has been achieved from methyl gallate by a proposed synthetic route of five steps, consisting of ketal protection, regioselective bromination, bis-lactonization, C–C bond formation between the aromatic rings of the galloyl groups, and ketal deprotection, in 38% overall yield. Ellagic acid showed a slight inhibitory activity against SARS-CoV-2 3CLpro.

Funder

Servier

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1941-1437.pdf

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